Another scientific article by Professor of the Department of Organic Synthesis and Bioorganic Chemistry of Samarkand State University Khurshid Bozorov “Discovery of novel (E)-1-methyl-9-(3-methylbenzylidene)-6,7,8,9-tetrahydropyrazolo[3,4-d ]pyrido[1,2-a]pyrimidin-4(1H)-one as DDR2 kinase inhibitor: Synthesis, molecular docking, and anticancer properties” was published in Bioorganic Chemistry, indexed in databases such as Scopus, SCI ( Web of Science) and PubMed [Q1, Impact Factor = 5.3, CiteScore = 7.1 Elsevier, Amsterdam, The Netherlands].

     The article is devoted to the synthesis of the newly synthesized pyrazole substance PP562, its inhibitory properties against 100 different kinase enzymes, its selective activity against human gastric cancer (HGC-27 cells), analysis of molecular docking, and a detailed mechanism of its action. activity against HGC-27 cancer cells.

      The article was prepared in collaboration with scientists from the Chinese Academy of Sciences. Head of the scientific project Khurshid Bozorov. The project consultant is Professor Haji Akber Aisa.

 

    More: https://www.sciencedirect.com/science/article/pii/S0045206823001669