Лабораториянинг йўналиши:

  • доривор ўсимликлар таркибидаги биологик фаол пиримидин ҳалқаси сақлаган алкаллоидларнинг синтетик аналогларини синтез қилиш;
  • истиқболли табиий ва синтетик моддаларни саратон ҳужайраларига қарши фаоллигини татбиқ қилиш;
  • янги бирикмаларнинг тузилишини фаолликка боғлиқлиги ва молекуляр докинг таҳлил усуллари;
  • биологик фаол табиий бирикмалар ҳамда уларнинг синтетик аналогларини микроорганизмлар иштирокида биотрансформация қилиш;
  • онкологияга йўналтирилган мақсадли синтезлар.

    Лабораториянинг эришган ютуқлари:

  • Хитой Фанлар Академияси тадқиқот институтлари илмий ходимлари билан ҳамкорлик ё'лга қўйилди. 2022- йилда 7 та халқаро патентлар олинди;
  • Лабораторияда конденсирланган пиримидинларнинг арзон ва бир босқичли синтези асосида амалий аҳамиятга эга истиқболли бирикмалар олиниб, натижалар патентлар ҳамда PubMED, Scopus ва Web of Science каби маълумотлар базасида индексланувчи нуфузли журналларда чоп қилинди;
  • Хитой, Италия, АҚШ ва Германия каби давлатларнинг илмий-тадқиқот гуруҳлари билан истиқболли лойиҳалар устида ишлар олиб борилаяпти.

    Лаборатория ходимлари рўйхати:

Бозоров Хуршед Абдуллойевич

к.ф.д. (DSc), катта илмий ходим

Email: khurshedbek@gmail.com; bozorov@samdu.uz

 

Насруллаев Азизбек Озодович, к.ф.н, доцент

Курязов Рустамхон Шоназарович, к.ф.н., доцент, (эркин тадқиқотчи)

Акрамов Давлат Химматкулович, (PhD), илмий ходим

Яхшиликова Лола Жўрабаевна,

(PhD), илмий ходим

Муртазаева Зарифа Исакуловна

таянч доктарант

Тургунов Даврон Элибекович

таянч доктарант

Буронов Анвар Юсуф ўғли таянч доктарант

Ғайбуллаев Шухрат Шароф ўғли

магистр

Илмий-тадқиқот лойиҳалари:

  • Chinese Academy of Sciences President’s International Fellowship Initiative (PIFI), Loyiha raqami: 2019PB0054, 2019, Xitoy Fanlar Akademiyasi hamkorligida.
  • Chinese Academy of Sciences President’s International Fellowship Initiative (PIFI), Loyiha raqami: 2016PT014, 2016, Xitoy Fanlar Akademiyasi hamkorligida.
  • National Natural Science Foundation of China (NSFC), Loyiha raqami: 21550110495, 2015, Xitoy Fanlar Akademiyasi hamkorligida.
  • National Natural Science Foundation of China (NSFC), Loyiha raqami: 21550110495, 2014, Xitoy Fanlar Akademiyasi hamkorligida.

Лаборатория ходимларининг илмий ишлари:

ПАТЕНТЛАР

1. H.A. Aisa, K. Bozorov, J.Y. Zhao, C. Niu, Kh. Shakhidoyatov. Preparation and biological application of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives, (2016) Patent CN 104016963B (PR China).

2. H.A. Aisa, B. Song, L.F. Nie, J.Y. Zhao, K. Bozorov. Tricyclic furo[2,3-d]pyrimidone compound and application thereof, (2022) Patent CN CN113105469B (PR China).

3. H.A. Aisa, Y. Zeng, L. Nie, K. Bozorov, J. Zhao. Dihydrooxazolo[5,4-d]pyrrolo[1,2-a]pyrimidin-9(5H)-one derivatives and use thereof, (2022) Patent CN112724157B (PR China).

4. H.A. Aisa, Y. Zeng, L. Nie, K. Bozorov, J. Zhao. Tetrahydrooxazolopyridino-azoxanone derivative and application thereof, (2022) Patent CN112778333B (PR China).

5. H.A. Aisa, Y. Zeng, L. Nie, K. Bozorov, J. Zhao. Oxazolo[5,4-d]pyrido[1,2-a]pyrimidone derivative and application thereof, (2022) Patent CN112851692B (PR China).

6. H.A. Aisa, Y. Zeng, L. Nie, K. Bozorov, J. Zhao. Tricyclic thiazolo[5,4-d]pyrimidone derivative and application thereof, (2022) Patent CN113788846A (PR China).

7. H.A. Aisa, Z. Ruzi, L. Nie, K. Bozorov, J. Zhao. Pyrazolo[3,4-d]pyrrolo[1,2-a]pyrimidone arylene derivative and application thereof, (2022) Patent CN114478549A (PR China).

8. H.A. Aisa, Z. Ruzi, L. Nie, K. Bozorov, J. Zhao. m-Methyl benzylidene tetrahydropyrazole[3,4-d]pyridine[1,2-a]pyrimidone compound B and application thereof, (2022) Patent CN115141200A (PR China).

ШАРҲЛИ МАҚОЛАЛАР

1. N. Rustamova, K. Bozorov, T. Yefferth, A. Yili, Novel secondary metabolites from yendophytic fungi: synthesis and biological properties, Phytochemistry Reviews, 19 (2020) 425-448.

2. K. Bozorov, J. Zhao, H.A. Aisa, 1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview, Bioorganic & Medicinal Chemistry, 27 (2019) 3511-3531.

3. K. Bozorov, L.F. Nie, J. Zhao, H.A. Aisa, 2-Aminothiophene scaffolds: Diverse biological and pharmacological attributes in medicinal chemistry, Yeuropean Journal of Medicinal Chemistry, 140 (2017) 465-493.

4. K. Bozorov, J.-Y. Zhao, H.A. Aisa, Recent advances in ipso-nitration reactions, ARKIVOC, (2017) 41-66.

5. K. Bozorov, J.-Y. Zhao, B. Yelmuradov, A. Pataer, H.A. Aisa, Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties, Yeuropean Journal of Medicinal Chemistry, 102 (2015) 552-573.

МАҚОЛАЛАР (Scopus ва Web of Science, 2018-2023 йиллар)

6. Z. Ruzi, K. Bozorov, L. Nie, J. Zhao, H.A. Aisa, Discovery of novel (Ye)-1-methyl-9-(3-methylbenzylidene)-6,7,8,9-tetrahydropyrazolo[3,4-d]pyrido[1,2-a]pyrimidin-4(1H)-one as DDR2 kinase inhibitor: Synthesis, molecular docking, and anticancer properties, Bioorganic Chemistry 135C (2023) 106506.

7. Z. B. Song, L. Nie, K. Bozorov, C. Niu, R. Kuryazov, H.A. Aisa, J. Zhao, Furo[2,3-d]pyrimidines as Mackinazolinone/Isaindigotone Analogs: Synthesis, Modification, Antitumor Activity, and Molecular Docking Study, Chemistry & Biodiversity (2023). https://doi.org/10.1002/cbdv.202201059

8. B. Song, L. Nie, K. Bozorov, R. Kuryazov, H.A. Aisa, J. Zhao, Parallel synthesis of condensed pyrimidine-thiones and their antitumor activities, Research on Chemical Intermediates, 49 (2023) 1327–1348. https://doi.org/10.1007/s11164-022-04912-5

9. Z. Ruzi, K. Bozorov, L. Nie, J. Zhao, H.A. Aisa, Novel pyrazolo[3,4-d]pyrimidines as potential anticancer agents: Synthesis, VEGFR-2 inhibition, and mechanisms of action, Biomedicine & Pharmacotherapy, 156 (2022) 113948.

10. B. Song, L. Nie, K. Bozorov, R. Kuryazov, J. Zhao, H.A. Aisa, Design, combinatorial synthesis and cytotoxic activity of 2-substituted furo[2,3-d]pyrimidinone and pyrrolo[2,3-d]pyrimidinone library, Molecular Diversity, (2022). https://doi.org/10.1007/s11030-022-10529-y

11. Y. Zeng, L. Nie, L. Liu, C. Niu, Y. Li, K. Bozorov, J. Zhao, J. S’hen, H.A. Aisa, Design, synthesis, in vitro yevaluation of a new pyrrolo[1,2-a]thiazolo[5,4-d]pyrimidinone derivatives as cholinesterase inhibitors against Alzheimer's disease, Journal of Heterocyclic Chemistry, (2022).

12. H. Guo, L. Nie, K. Bozorov, H.A. Aisa, J. Zhao, Synthesis and Antitumor Activity of Novel Linear Tricyclic Compounds Derived from Purine, Heterocycles, 104 (2022) 1085-1097.

13. Y. Zeng, L. Nie, C. Niu, A. Mamatjan, K. Bozorov, J. Zhao, H.A. Aisa, Synthesis and Biological Activities of Dihydrooxazolo[5,4-d]-pyrrolo[1,2-a]pyrimidinones, Chinese Journal of Organic Chemistry, 42 (2022) 543-556.

14. Y. Zeng, L. Nie, K. Bozorov, Z. Ruzi, B. Song, J. Zhao, H.A. Aisa, 2-substituted tricyclic oxazolo[5,4-d]pyrimidine library: Design, synthesis, and cytotoxicity activity, Journal of Heterocyclic Chemistry, 59 (2022) 555-568.

15. K. Lin, X. Zhang, X. Dai, L. Ma, K. Bozorov, H. Guo, G. Huang, J. Cao, Synthesis and Anticancer Activity of Podophyllotoxin Derivatives, Chemistry of Natural Compounds, 57 (2021) 1010-1018.

16. L. Chen, M. Obul, K. Bozorov, J. Zhao, Synthesis and Antiviral Activity of New Derivatives of Rupestonic Acid, Chemistry of Natural Compounds, 57 (2021) 854-860.

17. Z. Ruzi, L. Nie, K. Bozorov, J. Zhao, H.A. Aisa, Synthesis and anticancer activity of yethyl 5-amino-1-N-substituted-imidazole-4-carboxylate building blocks, Archiv der Pharmazie, 354 (2021)  е2000470.

18. A. Nasrullaev, K. Bozorov, K. Bobakulov, J. Zhao, L.F. Nie, K.K. Turgunov, B. Yelmuradov, H.A. Aisa, Synthesis, characterization, and antimicrobial activity of novel hydrazone-bearing tricyclic quinazolines, Research on Chemical Intermediates, 45 (2019) 2287-2300.

19. L.F. Nie, G. Huang, K. Bozorov, J. Zhao, C. Niu, S.S. Sagdullaev, H.A. Aisa, Diversity-oriented synthesis of amide derivatives of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones and yevaluation of their influence on melanin synthesis in murine B16 cells, Heterocyclic Communications, 24 (2018) 43-50.

20. ​L.F. Nie, K. Bozorov, G. Huang, J. Zhao, C. Niu, H.A. Aisa, Design, synthesis, and toward a side-ring optimization of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones and their yeffect on melanin synthesis in murine B16 cells, Phosphorus, Sulfur, and Silicon and the Related Yelements, 193 (2018) 656-667.

21. F. Liu, X. Hou, L.F. Nie, K. Bozorov, M. Decker, G. Huang, A Convenient One-pot Synthesis of 2,3-Disubstituted Thieno[2,3-d]pyrimidin-4(3H)-ones from 2H-Thieno[2,3-d][1,3]oxazine-2,4(1H)-diones, Aromatic Aldehydes and Amines, SynOpen, 02 (2018) 0207-0212.