Laboratoriyaning yoʻnalishi:

  • dorivor oʻsimliklar tarkibidagi biologik faol pirimidin halqasi saqlagan alkalloidlarning sintetik analoglarini sintez qilish;
  • istiqbolli tabiiy va sintetik moddalarni saraton hujayralariga qarshi faolligini tadbiq qilish; 
  • yangi birikmalarning tuzilishini faollikka bogʻliqligi va molekulyar doking tahlil usullari;
  • biologik faol tabiiy birikmalar hamda ularning sintetik analoglarini mikroorganizmlar ishtirokida biotransformatsiya qilish;
  • onkologiyaga yoʻnaltirilgan maqsadli sintezlar.

    Laboratoriyaning erishgan yutuqlari:

  • Xitoy Fanlar Akademiyasi tadqiqot institutlari ilmiy xodimlari bilan hamkorlik yo'lga qoʻyildi. 2022- yilda 7 ta xalqaro patentlar olindi;
  • Laboratoriyada kondensirlangan pirimidinlarning arzon va bir bosqichli sintezi asosida amaliy ahamiyatga eka istiqbolli birikmalar olinib, natijalar patentlar hamda PubMED, Scopus va Web of Science kabi ma’lumotlar bazasida indekslanuvchi nufuzli jurnallarda chop qilindi;
  • Xitoy, Italiya, AQSh va Germaniya kabi davlatlarning ilmiy-tadqiqot guruhlari bilan istiqbolli loyihalar ustida ishlar olib borilayapti.

    Laboratoriya xodimlari roʻyxati:

Bozorov Xurshed Abdulloyevich

k.f.d. (DSc), katta ilmiy xodim

Email: khurshedbek@gmail.com; bozorov@samdu.uz

Nasrullayev Azizbek Ozodovich, k.f.n, dotsent

Kuryazov Rustamxon Shonazarovich, k.f.n., dotsent, (erkin tadqiqotchi)

Akramov Davlat Ximmatkulovich, (PhD), ilmiy xodim

Yaxshilikova Lola Joʻrabayevna,

(PhD), ilmiy xodim

Murtazayeva Zarifa Isakulovna

tayanch doktarant

 

Turgunov Davron Elibekovich

tayanch doktarant

 

Buronov Anvar Yusuf oʻgʻli

tayanch doktarant

 

Gʻaybullayev Shuxrat Sharof oʻgʻli

magistr

 

Ilmiy-tadqiqot loyihalari:

  • Chinese Academy of Sciences President’s International Fellowship Initiative (PIFI), Loyiha raqami: 2019PB0054, 2019, Xitoy Fanlar Akademiyasi hamkorligida.
  • Chinese Academy of Sciences President’s International Fellowship Initiative (PIFI), Loyiha raqami: 2016PT014, 2016, Xitoy Fanlar Akademiyasi hamkorligida.
  • National Natural Science Foundation of China (NSFC), Loyiha raqami: 21550110495, 2015, Xitoy Fanlar Akademiyasi hamkorligida.
  • National Natural Science Foundation of China (NSFC), Loyiha raqami: 21550110495, 2014, Xitoy Fanlar Akademiyasi hamkorligida.

Laboratoriya xodimlarining ilmiy ishlari:

PATENTLAR

1. H.A. Aisa, K. Bozorov, J.Y. Zhao, C. Niu, Kh. Shakhidoyatov. Preparation and biological application of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives, (2016) Patent CN 104016963B (PR China).

2. H.A. Aisa, B. Song, L.F. Nie, J.Y. Zhao, K. Bozorov. Tricyclic furo[2,3-d]pyrimidone compound and application thereof, (2022) Patent CN CN113105469B (PR China).

3. H.A. Aisa, Y. Zeng, L. Nie, K. Bozorov, J. Zhao. Dihydrooxazolo[5,4-d]pyrrolo[1,2-a]pyrimidin-9(5H)-one derivatives and use thereof, (2022) Patent CN112724157B (PR China).

4. H.A. Aisa, Y. Zeng, L. Nie, K. Bozorov, J. Zhao. Tetrahydrooxazolopyridino-azoxanone derivative and application thereof, (2022) Patent CN112778333B (PR China).

5. H.A. Aisa, Y. Zeng, L. Nie, K. Bozorov, J. Zhao. Oxazolo[5,4-d]pyrido[1,2-a]pyrimidone derivative and application thereof, (2022) Patent CN112851692B (PR China).

6. H.A. Aisa, Y. Zeng, L. Nie, K. Bozorov, J. Zhao. Tricyclic thiazolo[5,4-d]pyrimidone derivative and application thereof, (2022) Patent CN113788846A (PR China).

7. H.A. Aisa, Z. Ruzi, L. Nie, K. Bozorov, J. Zhao. Pyrazolo[3,4-d]pyrrolo[1,2-a]pyrimidone arylene derivative and application thereof, (2022) Patent CN114478549A (PR China).

8. H.A. Aisa, Z. Ruzi, L. Nie, K. Bozorov, J. Zhao. m-Methyl benzylidene tetrahydropyrazole[3,4-d]pyridine[1,2-a]pyrimidone compound B and application thereof, (2022) Patent CN115141200A (PR China).

SHARHLI MAQOLALAR

1. N. Rustamova, K. Bozorov, T. Efferth, A. Yili, Novel secondary metabolites from endophytic fungi: synthesis and biological properties, Phytochemistry Reviews, 19 (2020) 425-448.

2. K. Bozorov, J. Zhao, H.A. Aisa, 1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview, Bioorganic & Medicinal Chemistry, 27 (2019) 3511-3531.

3. K. Bozorov, L.F. Nie, J. Zhao, H.A. Aisa, 2-Aminothiophene scaffolds: Diverse biological and pharmacological attributes in medicinal chemistry, European Journal of Medicinal Chemistry, 140 (2017) 465-493.

4. K. Bozorov, J.-Y. Zhao, H.A. Aisa, Recent advances in ipso-nitration reactions, ARKIVOC, (2017) 41-66.

5. K. Bozorov, J.-Y. Zhao, B. Elmuradov, A. Pataer, H.A. Aisa, Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties, European Journal of Medicinal Chemistry, 102 (2015) 552-573.

MAQOLALAR (Scopus va Web of Science, 2018-2023 yillar)

6. Z. Ruzi, K. Bozorov, L. Nie, J. Zhao, H.A. Aisa, Discovery of novel (E)-1-methyl-9-(3-methylbenzylidene)-6,7,8,9-tetrahydropyrazolo[3,4-d]pyrido[1,2-a]pyrimidin-4(1H)-one as DDR2 kinase inhibitor: Synthesis, molecular docking, and anticancer properties, Bioorganic Chemistry 135C (2023) 106506.

7. Z. B. Song, L. Nie, K. Bozorov, C. Niu, R. Kuryazov, H.A. Aisa, J. Zhao, Furo[2,3-d]pyrimidines as Mackinazolinone/Isaindigotone Analogs: Synthesis, Modification, Antitumor Activity, and Molecular Docking Study, Chemistry & Biodiversity (2023). https://doi.org/10.1002/cbdv.202201059

8. B. Song, L. Nie, K. Bozorov, R. Kuryazov, H.A. Aisa, J. Zhao, Parallel synthesis of condensed pyrimidine-thiones and their antitumor activities, Research on Chemical Intermediates, 49 (2023) 1327–1348. https://doi.org/10.1007/s11164-022-04912-5

9. Z. Ruzi, K. Bozorov, L. Nie, J. Zhao, H.A. Aisa, Novel pyrazolo[3,4-d]pyrimidines as potential anticancer agents: Synthesis, VEGFR-2 inhibition, and mechanisms of action, Biomedicine & Pharmacotherapy, 156 (2022) 113948.

10. B. Song, L. Nie, K. Bozorov, R. Kuryazov, J. Zhao, H.A. Aisa, Design, combinatorial synthesis and cytotoxic activity of 2-substituted furo[2,3-d]pyrimidinone and pyrrolo[2,3-d]pyrimidinone library, Molecular Diversity, (2022). https://doi.org/10.1007/s11030-022-10529-y

11. Y. Zeng, L. Nie, L. Liu, C. Niu, Y. Li, K. Bozorov, J. Zhao, J. Shen, H.A. Aisa, Design, synthesis, in vitro evaluation of a new pyrrolo[1,2-a]thiazolo[5,4-d]pyrimidinone derivatives as cholinesterase inhibitors against Alzheimer's disease, Journal of Heterocyclic Chemistry, (2022).

12. H. Guo, L. Nie, K. Bozorov, H.A. Aisa, J. Zhao, Synthesis and Antitumor Activity of Novel Linear Tricyclic Compounds Derived from Purine, Heterocycles, 104 (2022) 1085-1097.

13. Y. Zeng, L. Nie, C. Niu, A. Mamatjan, K. Bozorov, J. Zhao, H.A. Aisa, Synthesis and Biological Activities of Dihydrooxazolo[5,4-d]-pyrrolo[1,2-a]pyrimidinones, Chinese Journal of Organic Chemistry, 42 (2022) 543-556.

14. Y. Zeng, L. Nie, K. Bozorov, Z. Ruzi, B. Song, J. Zhao, H.A. Aisa, 2-substituted tricyclic oxazolo[5,4-d]pyrimidine library: Design, synthesis, and cytotoxicity activity, Journal of Heterocyclic Chemistry, 59 (2022) 555-568.

15. K. Lin, X. Zhang, X. Dai, L. Ma, K. Bozorov, H. Guo, G. Huang, J. Cao, Synthesis and Anticancer Activity of Podophyllotoxin Derivatives, Chemistry of Natural Compounds, 57 (2021) 1010-1018.

16. L. Chen, M. Obul, K. Bozorov, J. Zhao, Synthesis and Antiviral Activity of New Derivatives of Rupestonic Acid, Chemistry of Natural Compounds, 57 (2021) 854-860.

17. Z. Ruzi, L. Nie, K. Bozorov, J. Zhao, H.A. Aisa, Synthesis and anticancer activity of ethyl 5-amino-1-N-substituted-imidazole-4-carboxylate building blocks, Archiv der Pharmazie, 354 (2021)  e2000470.

18. A. Nasrullaev, K. Bozorov, K. Bobakulov, J. Zhao, L.F. Nie, K.K. Turgunov, B. Elmuradov, H.A. Aisa, Synthesis, characterization, and antimicrobial activity of novel hydrazone-bearing tricyclic quinazolines, Research on Chemical Intermediates, 45 (2019) 2287-2300.

19. L.F. Nie, G. Huang, K. Bozorov, J. Zhao, C. Niu, S.S. Sagdullaev, H.A. Aisa, Diversity-oriented synthesis of amide derivatives of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones and evaluation of their influence on melanin synthesis in murine B16 cells, Heterocyclic Communications, 24 (2018) 43-50.

20. ​L.F. Nie, K. Bozorov, G. Huang, J. Zhao, C. Niu, H.A. Aisa, Design, synthesis, and toward a side-ring optimization of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones and their effect on melanin synthesis in murine B16 cells, Phosphorus, Sulfur, and Silicon and the Related Elements, 193 (2018) 656-667.

21. F. Liu, X. Hou, L.F. Nie, K. Bozorov, M. Decker, G. Huang, A Convenient One-pot Synthesis of 2,3-Disubstituted Thieno[2,3-d]pyrimidin-4(3H)-ones from 2H-Thieno[2,3-d][1,3]oxazine-2,4(1H)-diones, Aromatic Aldehydes and Amines, SynOpen, 02 (2018) 0207-0212.

Laboratoriya xodimlari fotogalereyasi